CYSTEINE: (Kidney Stones)
·
apoptotic process
Definition: A programmed cell death process which
begins when a cell receives an internal (e.g. DNA damage) or external signal
(e.g. an extracellular death ligand), and proceeds through a series of
biochemical events (signaling pathway phase) which trigger an execution phase.
The execution phase is the last step of an apoptotic process and is typically
characterized by rounding-up of the cell, retraction of pseudopods, reduction
of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation
(karyorrhexis), plasma membrane blebbing and fragmentation of the cell into
apoptotic bodies. When the execution phase is completed, the cell has died.
·
autophagy
Definition: The cellular catabolic process in which
cells digest parts of their own cytoplasm; allows for both recycling of
macromolecular constituents under conditions of cellular stress and remodeling
the intracellular structure for cell differentiation.
·
mitophagy
Definition: The selective autophagy process in which a
mitochondrion is degraded by macroautophagy.
·
protein delipidation
Definition: The breakage of covalent bonds to detach
lipid groups from a protein.
·
protein localization to phagophore
assembly site
Definition: Any process in which a protein is
transported to, or maintained at, the phagophore assembly site (PAS).
·
protein transport
Definition: The directed movement of proteins into,
out of or within a cell, or between cells, by means of some agent such as a
transporter or pore.
·
proteolysis
Definition: The hydrolysis of proteins into smaller
polypeptides and/or amino acids by cleavage of their peptide bonds.
TYPE IV COLLAGEN: (Alport Syndrome)
Biological Processes:
·
blood vessel development
Definition: The process whose specific outcome is the
progression of a blood vessel over time, from its formation to the mature
structure. The blood vessel is the vasculature carrying blood.
·
bone trabecula formation
Definition: The process of creating a trabecula in the
bone. A trabecula is a tissue element in the form of a small beam, strut or
rod.
·
cartilage development involved in
endochondral bone morphogenesis
Definition: The process whose specific outcome is the
progression of the cartilage that will provide a scaffold for mineralization of
endochondral bones.
·
cellular response to amino acid
stimulus
Definition: Any process that results in a change in
state or activity of a cell (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of an amino acid stimulus. An
amino acid is a carboxylic acid containing one or more amino groups.
·
cellular response to epidermal growth
factor stimulus
Definition: Any process that results in a change in
state or activity of a cell (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of an epidermal growth factor
stimulus.
·
cellular response to fibroblast
growth factor stimulus
Definition: Any process that results in a change in
state or activity of a cell (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of an fibroblast growth factor
stimulus.
·
cellular response to fluoride
Definition: Any process that results in a change in
state or activity of a cell (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of a fluoride stimulus.
·
cellular response to mechanical stimulus
Definition: Any process that results in a change in
state or activity of a cell (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of a mechanical stimulus.
·
cellular response to retinoic acid
Definition: Any process that results in a change in
state or activity of a cell (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of a retinoic acid stimulus.
·
cellular response to transforming
growth factor beta stimulus
Definition: Any process that results in a change in
state or activity of a cell (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of a transforming growth factor
beta stimulus.
·
cellular response to tumor necrosis
factor
Definition: Any process that results in a change in state
or activity of a cell (in terms of movement, secretion, enzyme production, gene
expression, etc.) as a result of a tumor necrosis factor stimulus.
·
cellular response to vitamin E
Definition: Any process that results in a change in state
or activity of a cell (in terms of movement, secretion, enzyme production, gene
expression, etc.) as a result of a vitamin E stimulus.
·
collagen-activated tyrosine kinase
receptor signaling pathway
Definition: The series of molecular signals initiated by
collagen binding to its receptor on the surface of a target cell where the
receptor possesses tyrosine kinase activity, and ending with the regulation of
a downstream cellular process, e.g. transcription.
·
collagen biosynthetic process
Definition: The chemical reactions and pathways resulting
in the formation of collagen, any of a group of fibrous proteins of very high
tensile strength that form the main component of connective tissue in animals.
Collagen is highly enriched in glycine (some regions are 33% glycine) and
proline, occurring predominantly as 3-hydroxyproline (about 20%).
·
collagen fibril organization Source:
Definition: Any process that determines the size and
arrangement of collagen fibrils within an extracellular matrix.
·
embryonic skeletal system development
Definition: The process, occurring during the embryonic
phase, whose specific outcome is the progression of the skeleton over time,
from its formation to the mature structure.
·
endochondral ossification
Definition: Replacement ossification wherein bone tissue
replaces cartilage.
·
extracellular matrix organization
Definition: A process that is carried out at the cellular
level which results in the assembly, arrangement of constituent parts, or
disassembly of an extracellular matrix.
·
face morphogenesis
Definition: The process in which the anatomical structures
of the face are generated and organized. The face is the ventral division of
the head.
·
intramembranous ossification
Definition: Direct ossification that occurs within
mesenchyme or an accumulation of relatively unspecialized cells.
·
negative regulation of cell-substrate
adhesion
Definition: Any process that decreases the frequency, rate
or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment
of a cell to the underlying substrate via adhesion molecules.
·
Ossification
Definition: The formation of bone or of a bony substance,
or the conversion of fibrous tissue or of cartilage into bone or a bony
substance.
·
osteoblast differentiation
Definition: The process whereby a relatively unspecialized
cell acquires the specialized features of an osteoblast, a mesodermal or neural
crest cell that gives rise to bone.
·
positive regulation of canonical Wnt
signaling pathway
Definition: Any process that increases the rate, frequency,
or extent of the Wnt signaling pathway through beta-catenin, the series of
molecular signals initiated by binding of a Wnt protein to a frizzled family
receptor on the surface of the target cell, followed by propagation of the
signal via beta-catenin, and ending with a change in transcription of target
genes.
·
positive regulation of cell migration
Definition: Any process that activates or increases the
frequency, rate or extent of cell migration.
·
positive regulation of epithelial to
mesenchymal transition
Definition: Any process that increases the rate, frequency,
or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal
transition is where an epithelial cell loses apical/basolateral polarity,
severs intercellular adhesive junctions, degrades basement membrane components
and becomes a migratory mesenchymal cell.
·
positive regulation of transcription,
DNA-templated
Definition: Any process that activates or increases the
frequency, rate or extent of cellular DNA-templated transcription.
·
protein localization to nucleus
Definition: A process in which a protein transports or
maintains the localization of another protein to the nucleus.
·
protein transport
Definition: The directed movement of proteins into, out of
or within a cell, or between cells, by means of some agent such as a
transporter or pore.
·
response to cAMP
Definition: Any process that results in a change in state
or activity of a cell or an organism (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine
3',5'-cyclophosphate) stimulus.
·
response to corticosteroid
Definition: Any process that results in a change in state
or activity of a cell or an organism (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of a corticosteroid hormone
stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal
cortex. Corticosteroids are involved in a wide range of physiologic systems
such as stress response, immune response and regulation of inflammation,
carbohydrate metabolism, protein catabolism, blood electrolyte levels, and
behavior. They include glucocorticoids and mineralocorticoids
·
response to estradiol
Definition: Any process that results in a change in state
or activity of a cell or an organism (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of stimulus by estradiol, a C18
steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
·
response to hydrogen peroxide
Definition: Any process that results in a change in state
or activity of a cell or an organism (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2)
stimulus.
·
response to hyperoxia
Definition: Any process that results in a change in state
or activity of a cell or an organism (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of a stimulus indicating
increased oxygen tension.
·
response to mechanical stimulus
Definition: Any process that results in a change in state
or activity of a cell or an organism (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of a mechanical stimulus.
·
response to peptide hormone
Definition: Any process that results in a change in state
or activity of a cell or an organism (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of a peptide hormone stimulus. A
peptide hormone is any of a class of peptides that are secreted into the blood
stream and have endocrine functions in living animals.
·
response to xenobiotic stimulus
Definition: Any process that results in a change in state
or activity of a cell or an organism (in terms of movement, secretion, enzyme
production, gene expression, etc.) as a result of a stimulus from a xenobiotic,
a compound foreign to the organim exposed to it. It may be synthesized by another
organism (like ampicilin) or it can be a synthetic chemical.
·
sensory perception of sound
Definition: The series of events required for an organism
to receive an auditory stimulus, convert it to a molecular signal, and
recognize and characterize the signal. Sonic stimuli are detected in the form
of vibrations and are processed to form a sound.
·
skeletal system development
Definition: The process whose specific outcome is the
progression of the skeleton over time, from its formation to the mature
structure. The skeleton is the bony framework of the body in vertebrates
(endoskeleton) or the hard outer envelope of insects (exoskeleton or
dermoskeleton).
·
skin development
Definition: The process whose specific outcome is the
progression of the skin over time, from its formation to the mature structure.
The skin is the external membranous integument of an animal. In vertebrates the
skin generally consists of two layers, an outer nonsensitive and nonvascular
epidermis (cuticle or skarfskin) composed of cells which are constantly growing
and multiplying in the deeper, and being thrown off in the superficial layers,
as well as an inner vascular dermis (cutis, corium or true skin) composed
mostly of connective tissue
·
skin morphogenesis
Definition: The process in which the anatomical structures
of the skin are generated and organized. The skin is the external membranous integument
of an animal. In vertebrates the skin generally consists of two layers, an
outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of
cells which are constantly growing and multiplying in the deeper, and being
thrown off in the superficial layers, as well as an inner, sensitive and
vascular dermis (cutis, corium or true skin) composed mostly of connective
tissue.
·
tooth eruption
Definition: The tooth development process in which the
teeth enter the mouth and become visible.
·
tooth mineralization
Definition: The process in which calcium salts are
deposited into calcareous tooth structures such as dental enamel, dentin and
cementum.
·
visual perception
Definition: The series of events required for an organism
to receive a visual stimulus, convert it to a molecular signal, and recognize
and characterize the signal. Visual stimuli are detected in the form of photons
and are processed to form an image.
·
wound healing
Definition: The series of events that restore integrity to
a damaged tissue, following an injury.
Polycystin-1:
GO - Biological process”
·
anatomical
structure morphogenesis
Definition:
The
process in which anatomical structures are generated and organized.
Morphogenesis pertains to the creation of form.
·
branching
morphogenesis of an epithelial tube
Definition:
The
process in which the anatomical structures of branches in an epithelial tube
are generated and organized. A tube is a long hollow cylinder.
·
calcium-independent
cell-matrix adhesion
Definition:
The binding of a cell to the extracellular matrix via
adhesion molecules that do not require the presence of calcium for the
interaction.
·
calcium ion
transmembrane transport
Definition:
A process in which a calcium ion is transported from one side
of a membrane to the other by means of some agent such as a transporter or pore.
Definition:
The directed movement of calcium (Ca) ions into, out of or
within a cell, or between cells, by means of some agent such as a transporter
or pore.
Definition:
The condensation of mesenchymal cells that have been
committed to differentiate into chondrocytes.
Definition:
The process whose specific outcome is the progression of a
cartilage element over time, from its formation to the mature structure.
Cartilage elements are skeletal elements that consist of connective tissue
dominated by extracellular matrix containing collagen type II and large amounts
of proteoglycan, particularly chondroitin sulfate.
Definition:
Any process that mediates the transfer of information from
one cell to another, medaited by a wnt family protein ligand. This process
includes wnt signal transduction in the receiving cell, release of wnt ligand
from a secreting cell as well as any processes that actively facilitate wnt
transport and presentation to receptor on the recieving cell.
Definition:
The binding of a cell to the extracellular matrix via
adhesion molecules.
· cytoplasmic
sequestering of transcription factor
Definition:
The selective interaction of a transcription factor with
specific molecules in the cytoplasm, thereby inhibiting its translocation into
the nucleus.
·
detection of mechanical
stimulus
Definition:
The series of events by which a mechanical stimulus is
received and converted into a molecular signal.
Definition:
The process whose specific outcome is the progression of the
digestive tract over time, from its formation to the mature structure. The
digestive tract is the anatomical structure through which food passes and is
processed.
·
embryonic
placenta development
Definition:
The embryonically driven process whose specific outcome is
the progression of the placenta over time, from its formation to the mature
structure. The placenta is an organ of metabolic interchange between fetus and
mother, partly of embryonic origin and partly of maternal origin.
·
establishment of
cell polarity
Definition:
The specification and formation of anisotropic intracellular
organization or cell growth patterns.
Definition:
The process whose specific outcome is the progression of the
genitalia over time, from its formation to the mature structure.
Definition:
The process whose specific outcome is the progression of the
heart over time, from its formation to the mature structure. The heart is a
hollow, muscular organ, which, by contracting rhythmically, keeps up the
circulation of the blood.
· homophilic cell
adhesion via plasma membrane adhesion molecules
Definition:
The attachment of a plasma membrane adhesion molecule in one
cell to an identical molecule in an adjacent cell.
·
in utero
embryonic development
Definition:
The process whose specific outcome is the progression of the
embryo in the uterus over time, from formation of the zygote in the oviduct, to
birth. An example of this process is found in Mus musculus.
Definition:
The process whose specific outcome is the progression of the
kidney over time, from its formation to the mature structure. The kidney is an
organ that filters the blood and/or excretes the end products of body
metabolism in the form of urine.
Definition:
The process whose specific outcome is the progression of the
liver over time, from its formation to the mature structure. The liver is an
exocrine gland which secretes bile and functions in metabolism of protein and
carbohydrate and fat, synthesizes substances involved in the clotting of the
blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen,
and breaks down worn-out erythrocytes.
Definition:
The biological process whose specific outcome is the
progression of the lung epithelium from an initial condition to its mature
state. This process begins with the formation of lung epithelium and ends with
the mature structure. The lung epithelium is the specialized epithelium that
lines the inside of the lung.
Definition:
The process in which the anatomical structures of lymph
vessels are generated and organized. The lymph vessel is the vasculature carrying
lymph.
·
mesonephric duct
development
Definition:
The process whose specific outcome is the progression of a
mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct
is a tube drains the mesonephros.
·
mesonephric
tubule development
Definition:
The progression of a mesonephric tubule over time, from its
initial formation to the mature structure. A mesonephric tubule is an
epithelial tube that is part of the mesonephros.
·
metanephric
ascending thin limb development
Definition:
The process whose specific outcome is the progression of a
metanephric ascending thin limb over time, from its formation to the mature
structure. The metanephric ascending thin limb is a segment of a nephron tubule
in the metanephros lying in the inner medulla that is permeable to ions but not
to water and has a simple epithelium; active transepithelial solute transport
is absent.
·
metanephric
collecting duct development
Definition:
The process whose specific outcome is the progression of a
metanephric ascending thin limb over time, from its formation to the mature
structure. The metanephric ascending thin limb is a segment of a nephron tubule
in the metanephros lying in the inner medulla that is permeable to ions but not
to water and has a simple epithelium; active transepithelial solute transport
is absent.
·
metanephric distal
tubule morphogenesis
Definition:
The progression of a mesonephric tubule over time, from its
initial formation to the mature structure. A mesonephric tubule is an
epithelial tube that is part of the mesonephros.
·
metanephric
proximal tubule development
Definition:
The process whose specific outcome is the progression of the
metanephric proximal tubule over time, from its formation to the mature
structure. The metanephric proximal tubule is a metanephric nephron tubule that
connects Bowman's capsule to the descending thin limb of the loop of Henle in
the metanephros. It has a brush border epithelial morphology.
Definition:
The process whose specific outcome is the progression of the
neural tube over time, from its formation to the mature structure. The mature
structure of the neural tube exists when the tube has been segmented into the
forebrain, midbrain, hindbrain and spinal cord regions. In addition neural
crest has budded away from the epithelium.
·
peptidyl-serine
phosphorylation
Definition:
The phosphorylation of peptidyl-serine to form
peptidyl-O-phospho-L-serine.
·
placenta blood
vessel development
Definition:
The process whose specific outcome is the progression of a
blood vessel of the placenta over time, from its formation to the mature
structure
·
positive
regulation of cyclin-dependent protein serine/threonine kinase activity
Definition:
Any process that activates or increases the frequency, rate
or extent of CDK activity.
·
positive
regulation of cytosolic calcium ion concentration
Definition:
Any process that increases the concentration of calcium ions
in the cytosol.
·
positive
regulation of protein binding
Definition:
Any process that activates or increases the frequency, rate
or extent of protein binding.
·
positive
regulation of transcription by RNA polymerase II
Definition:
Any process that activates or increases the frequency, rate
or extent of transcription from an RNA polymerase II promoter.
Definition:
The directed movement of a protein from the nucleus into the
cytoplasm.
·
protein
heterotetramerization
Definition:
The formation of a protein heterotetramer, a macromolecular
structure consisting of four noncovalently associated subunits, of which not
all are identical.
·
receptor
signaling pathway via JAK-STAT
Definition:
Any process in which STAT proteins (Signal Transducers and
Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a
signal to trigger a change in the activity or state of a cell. The receptor
signaling pathway via JAK-STAT begins with activation of a receptor and
proceeeds through STAT protein activation by members of the JAK family of
tyrosine kinases. STAT proteins dimerize and subsequently translocate to the
nucleus. The pathway ends with regulation of target gene expression by STAT
proteins.
Definition:
Any process that modulates the frequency, rate or extent of
attachment of a cell to another cell or to the extracellular matrix.
Definition:
Any process that modulates the rate or extent of progression
through the cell cycle.
·
regulation of
G1/S transition of mitotic cell cycle
Definition:
Any signalling pathway that modulates the activity of a cell
cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S
phase of the mitotic cell cycle.
·
regulation of mitotic
spindle organization
Definition:
Any process that modulates the rate, frequency or extent of
the assembly, arrangement of constituent parts, or disassembly of the
microtubule spindle during a mitotic cell cycle.
·
regulation of
proteasomal protein catabolic process
Definition:
Any process that modulates the rate, frequency, or extent of
the chemical reactions and pathways resulting in the breakdown of a protein or
peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
·
response to
fluid shear stress
Definition:
Any process that results in a change in state or activity of
a cell or an organism (in terms of movement, secretion, enzyme production, gene
expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear
stress is the force acting on an object in a system where the fluid is moving
across a solid surface.
Definition:
The process whose specific outcome is the progression of the
skin over time, from its formation to the mature structure. The skin is the
external membranous integument of an animal. In vertebrates the skin generally
consists of two layers, an outer nonsensitive and nonvascular epidermis
(cuticle or skarfskin) composed of cells which are constantly growing and
multiplying in the deeper, and being thrown off in the superficial layers, as
well as an inner vascular dermis (cutis, corium or true skin) composed mostly
of connective tissue.
Definition:
The process whose specific outcome is the progression of the
spinal cord over time, from its formation to the mature structure. The spinal
cord primarily conducts sensory and motor nerve impulses between the brain and
the peripheral nervous tissues.
V2
vasopressin:
Biological process:
·
activation of
adenylate cyclase activity
Definition:
Any process that initiates the activity of the inactive
enzyme adenylate cyclase.
·
adenylate
cyclase-modulating G protein-coupled receptor signaling pathway
Definition:
A G protein-coupled receptor signaling pathway in which the
signal is transmitted via the activation or inhibition of adenylyl cyclase
activity and a subsequent change in the intracellular concentration of cyclic
AMP (cAMP).
·
G
protein-coupled receptor signaling pathway
Definition:
The series of molecular signals initiated by a ligand binding
to its receptor, in which the activated receptor promotes the exchange of GDP
for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex.
The GTP-bound activated alpha-G-protein then dissociates from the beta- and
gamma-subunits to further transmit the signal within the cell. The pathway
begins with receptor-ligand interaction, and ends with regulation of a
downstream cellular process. The pathway can start from the plasma membrane,
Golgi or nuclear membrane
Definition:
The stopping of bleeding (loss of body fluid) or the arrest
of the circulation to an organ or part.
·
I-kappaB
kinase/NF-kappaB signaling
Definition:
The process in which a signal is passed on to downstream
components within the cell through the I-kappaB-kinase (IKK)-dependent
activation of NF-kappaB. The cascade begins with activation of a trimeric IKK
complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and
the regulatory scaffold protein NEMO) and ends with the regulation of
transcription of target genes by NF-kappaB. In a resting state, NF-kappaB
dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm.
Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal
degradation, thus releasing the NF-kappaB dimers, which can translocate to the
nucleus to bind DNA and regulate transcription
·
negative
regulation of cell population proliferation
Definition:
Any process that stops, prevents or reduces the rate or
extent of cell proliferation.
·
negative
regulation of renal sodium excretion
Definition:
Any process that decreases the amount of sodium excreted in
urine over a unit of time.
·
positive
regulation of cell population proliferation
Definition:
Any process that activates or increases the rate or extent of
cell proliferation.
·
positive
regulation of gene expression
Definition:
Any process that increases the frequency, rate or extent of
gene expression. Gene expression is the process in which a gene's coding
sequence is converted into a mature gene product (protein or RNA).
·
positive
regulation of systemic arterial blood pressure
Definition:
The process that increases the force with which blood travels
through the systemic arterial circulatory system.
·
positive
regulation of vasoconstriction
Definition:
Any process that activates or increases the frequency, rate
or extent of vasoconstriction.
·
regulation of
systemic arterial blood pressure by vasopressin
Definition:
The regulation of blood pressure mediated by the signaling
molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects
vasoconstriction, and renal water transport.
Definition:
The process in which renal water excretion is decreased.
Definition:
Any process that results in a change in state or activity of
a cell or an organism (in terms of movement, secretion, enzyme production, gene
expression, etc.) as a result of a cytokine stimulus.
Definition:
The process whose specific outcome is the progression of the
telencephalon over time, from its formation to the mature structure. The
telencephalon is the paired anteriolateral division of the prosencephalon plus
the lamina terminalis from which the olfactory lobes, cerebral cortex, and
subcortical nuclei are derived.
Siderocalin:
Biological process:
Definition:
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
Definition:
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
Definition:
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
Definition:
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis
Definition:
The process of binding or confining iron ions such that they are separated from other components of a biological system.
Definition:
The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.